21-P001 Developmental regulation and tissue patterning by Shh in vertebrate limbs
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چکیده
منابع مشابه
21-P001 Developmental regulation and tissue patterning by Shh in vertebrate limbs
During limb development, Sonic Hedgehog (Shh) is expressed in the posterior limb bud and is critical for the antero-posterio (AP) patterning of the limb. Gain or loss of Shh function affects patterning of limb skeletal elements, muscle, and tendons. However, it remains unknown whether Shh signalling regulates the patterning and development of these tissues in a cell-autonomous and non-cell-auto...
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متن کاملIFT56 regulates vertebrate developmental patterning by maintaining IFTB integrity and ciliary microtubule architecture
Cilia are key regulators of animal development and depend on intraflagellar transport (IFT) proteins to form and function, yet the roles of individual IFTs are still unclear. We examined the Ift56 mouse mutant and reveal novel insight into the function of IFT56, a poorly understood IFTB protein. Ift56 mice have normal cilia distribution but display defective cilia structure including abnormal p...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.866